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Cascading Style Sheets (or CSS for short) have slowly but surely become a website design standard over the past few years. It was not that many years ago that people used Frames to position their

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

content across their web pages and Tables gradually replaced this. Many low-end website developers are still very comfortable with Tables, as it ‘does what it says on the tin’. However, more and

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

more people are now moving over to CSS, as virtually all the layout options can be achieved using the code.

One major problem with CSS is that not all Web browsers produce the same results and i

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

has not been helped in the past by the various browsers employing their own way of interpreting certain CSS conventions. You can think your CSS design looks OK in the current version of your pre

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ferred browser and can then be crestfallen when you view your Web pages in another version that has destroyed the formatting. Therefore, when moving over to CSS, it is important that you use the

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

apabilities that are consistently supported across the entire range of popular browsers. It is interesting that the new version 7 of Microsoft's Internet Explorer has fixed a number of earlier an

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

malies, but many people are now waking up to the reality that IE7 has in fact caused problems arising from their earlier workarounds!

So why not bother with CSS, if Tables work for you? The prin

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

cipal advantages are as follows:

1. Web page code is generally much easier to follow;

2. The amount of code used to achieve the same result is much less. The general view is that by switching t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

a CSS layout, the typical page size reduction is between 50 - 60 per cent;

3. Download speeds for CSS pages are generally faster than their Table-driven counterparts. This is because browsers h

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ve to read through the table code twice before they are able to display the contents. They do this firstly to figure out the structure and then again to understand the content. It should also be

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ecognised that a Table's contents can only be presented to the screen in one go, whereas CSS content will drop in separately, thereby giving a better user experience. It is also possible to gover

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

n the order in which specific screen elements appear, so the user is not distracted by the more bulky and slower to load image files. Furthermore, because all the code involved with CSS page layo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t is held in one external CSS document and is cached, it is faster than Table layouts that need to be interpreted every time a new page is displayed;

4. It is much easier to edit existing pages

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nd to add new pages, particularly in the area of subtle formatting amendments. For example, you can change the font or colour scheme across an entire website in literally minutes;

5. CSS deliver

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s enhanced accessibility. In recent years the number of people using web browsers on hand-held devices has risen significantly and CSS plays an important function in delivering content to PDA's e

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

c through additional CSS documents. This just isn't possible with Table-driven layouts;

6. CSS is considered to be more Search Engine friendly because they can spider CSS pages quicker. However,

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

it remains to be seen if this has any tangible benefits such as an improvement on the your page ranking.

On the flipside, there are a few disadvantages to CSS web page design you should consider

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

:

1. As compared with Tables, CSS involves a much bigger learning curve;

2. Because of cross browser support issues, the time spent implementing workarounds should not be underestimated;

3. Ne

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

browser versions can catch website developers napping if you are not careful. You can find that earlier workarounds have been overcome and the look of your website has changed overnight.

Ultima

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ely, your decision on whether or not to move over to see CSS will probably depend on your level of technical capability and the time you're able to devote to understanding CSS layout alternatives

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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