E-Folder - Internet and Businesses Online

The online world is getting larger, and as the demand grows, so do the demands on the infrastructure. People want more, they want it faster and they want it now! So ho

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

w's your internet connection running? is it faster or slower than this time last year? In most cases it will have slowed down, maybe just a little. And when you look

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t the figures, that isn't really surprising.

One of the reasons things are slowing up a little is that every man, his dog and sister are involved in internet file shari

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ng. Simply speaking - masses of information is exchanging hands, often in the form of music or videos, which are very large. If you think of the major internet connect

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ons as a pipe and the information as the water - only so much water can flow through any single point of the pipe at one time. It's a lot - but it is finite, and that m

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ans if more than that limit is trying to flow through the pipe, things start to backup behind it. So when we are talking about speed, the less information is sharing th

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e same pipeline as you, the faster things are going to run. This is why new internet service providers often start up with a very quick service, but their connection sp

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

eds slow down as more and more customers join.

One form of information flowing through the pipeline is spam email. Now compared to a video these messages are tiny, but

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

there's also an awful lot of them. A high proportion of spam emails contain pictures, which again, while smaller than videos and music, take up space and bandwidth.

So

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

a spam message will have a small effect on the flow of traffic and overall internet speeds right? Well yes, but the problem with spam, as we know is they don't come on

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

at a time, and they use whatever method necessary to get mail through. Let's try an analogy. There's a fly in your house. It buzzes around and annoys you a little by

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

landing on your arm while you are trying to type informative and interesting articles. It's annoying, and you consider getting out the fly spray for that fly, but you'l

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

l just finish typing first. Flies are irritating, but they aren't THAT irritating. Now let's say instead of one fly - there were 70 million. You can't even get to the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

fly spray because they are crawling over every surface. Even if you did spray and kill them all, they would pile up to your chin in a dead heap on the floor. And as so

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

n as they died a new one would come take their place anyway. Now they become a real problem. It's not the actual spam, it's the amount of spam. It's not a one off nui

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

sance, it's a continual flood of messages send over and over.

Now not only are all these messages taking up bandwidth, but there is an expectation that ISP's will make

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ome sort of effort to save you from receiving all this spam. So when you pay for your internet connection, not only are you paying the connection, but also for your ISP

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s spam fighting efforts - which probably include a few dedicated machines and staff. If you think spam is annoying now, imagine what it would be like if there weren't p

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

eople in ISP's dedicated to stopping the flow of it?

It's not just a simple problem, and it's not just an inconvenience. It is an internet disease, and everyone can be

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

infected. Even those who get off lightly in the amount of actual spam mail they receive are affected - their internet speed is compromised and their costs are increased

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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No matter what someone tells you, it is extremely unlikely that it will happen overnight and that it will be straight-forward and easy. The business world outside of the Internet is not like that and while the Internet has some amazing and unique characteristics, the basic principles of hard work, dedication, learning lessons, focusing on a goal and never giving up are just as true.

After the recent success of the Million Dollar Homepage, a large number of copy cat sites and people offering free scripts have started to show up, all with the same promises, that you too can make a million just by launching a pixel site. A quick browse through eBay shows hundreds of these so called pixel sites, available for as little as $5 or $100, depending on how deep you look. So can lightening strike twice, is it really possible that you can experience the same kind of success as the original Million Dollar Homepage?

What was your long-term attitude towards that person's future emails? If you are like me, you stopped opening those emails. What can you deduce from your own behavior as shown by these questions? What I come up with is that you have to be very careful what you put in your emails...

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