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Last year I came across a poster on Yahoo! Answers asking for advice on a strange e-mail she received. According to this poster she received a reply from someone on an e-mail she never sent. She immediately thought that the spammer hacked her e-m

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ail account, sent an e-mail to himself and then replied to it. This is not impossible, but there are easier ways to do this, without hacking an e-mail account.

E-mails are plain text documents and can be modified and manipulated with a simple te

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t editor like Notepad. The spammer simply saves any e-mail to a file, opens it with Notepad and puts your e-mail address in the “From” field. The spammer then imports it into an e-mail client and replies to this manipulated e-mail. This is only o

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ne of many ways to manipulate an e-mail message.

Spammers normally use a technique called hash busting. Hash busting is when you add random text at the beginning or at the end of an e-mail. The text makes no sense and consists of excerpts from b

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

oks, articles and news bulletins. This text randomises the size, as well as the contents of the e-mail, making it hard for spam filters to find a pattern in the e-mail to base its filtering decisions on. For instance, an e-mail consisting of an i

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

mage only will normally be flagged as spam, but if someone adds random text below the image, it changes the pattern of the e-mail and the spam filter can no longer use the criteria mentioned earlier to label the e-mail as spam. There are legitima

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e e-mails like this and the spam filter needs additional training to know which e-mails with embedded images, containing text below the image, are spam and which ones are not.

Some spammers realised that people became suspicious of the senseless

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

text in spam e-mails, so they started to hide the text by making the colour of the text the same as the background colour. Other spammers make the size of the text so small that it appears like a horizontal line between paragraphs or at the bott

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

m of the e-mail. The techniques used to conceal the hash buster text are easily detectable by a good spam filter because no decent person will send someone else an e-mail with hidden text or text that cannot be seen with the naked eye. So the spa

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

mmers fail more often to get their e-mails through the spam filters when they use cloaking techniques like this.

Spammers needed a way to make the hash buster text look legitimate to the user as well as the spam filter. This is when they came up

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

with the idea of pretending to reply to an e-mail message that was never really sent to them in the first place. The spammer creates the forged e-mail with hash buster text and then replies to it. The spammer still enjoys the benefits of the hash

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

buster text coupled with a better chance to get past any spam filter, because the e-mail appears like a legitimate reply to a previous e-mail sent by the victim. A reply to an e-mail you sent to someone else is seldom unwanted and the spam filter

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

will therefore be less suspicious about it, unless it contains specific keywords and phrases that trigger the spam filter.

But there are more consequences for the victim than just a spam filter not being able to filter the e-mail as spam. Spamm

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rs can include anything in these fake e-mails. They can even pretend that you enquired about one of their products. Instead of spamming you with an unwanted e-mail, they pretend to send you a reply to your initial enquiry, an enquiry you never se

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

nt. Abuse departments can easily use this as an excuse not to take action against the spammer. They may argue that the spam victim did not receive an unwanted commercial e-mail, because the victim enquired about something and the accused simply r

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

plied to that enquiry. Luckily abuse departments need to prove that the original e-mail was really sent before rejecting the complaint, but we all know that very few abuse departments actually take any spam reports serious these days.

It is beca

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

use of the lack of proper legislation and poor implementation and enforcement of existing legislation that we have to deal with waves of spam every day. We are constantly one step behind cyber criminals and our current spam filters cannot keep up

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

with all the tricks and techniques used by spammers to force their junk down our throats. There is a widespread appeal for better filtering and alternative communication methods. There is merit in developing better spam filters, but how do you re

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

place a communication medium like e-mail without disrupting individuals and businesses that depend on it every day to stay in contact with friends, family and clients? What’s the use of taking away a communication medium if you do not take action

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

against the individuals who abuse it? It will only be a matter of time before spammers start to abuse the system replacing e-mail. You need to take action against the root of the problem and not the infrastructure through which the problem occurs

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.e-folder.org.ua/article/81058/e-folder-Spammers-Replying-To-EMail-You-Did-Not-Send.html">Spammers Replying To E-Mail You Did Not Send</a>

BB link (for phorums):
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I am telling you this principle is crucial to your business. It can literally turn your business into a client focused, maximized profit leader in your industry.

One of the main factors which affects the performance of individuals at all levels within an organisation is the way in which the organisation itself develops and changes in time. Such changes are often closely related to a company’s growth but not necessarily; developments can clearly take place in an organisation which is not increasing in size as such.

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