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    There are just a few audio compression formats out there, just like there are on
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    ly a few image compression formats (you may have heard of them: JPG, GIF, BMP).
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    Two of the most popular audio formats are WMA, or Windows Media Audio, and MP3 (
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    Short for MPEG, Moving Pictures Experts Group, Audio Layer 3). WMA is the older
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    audio format, produced by Microsoft, to work with Microsoft's Windows media play
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    er. The WMA compression format was designed specifically for this format, and th
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    us can not be converted to other audio formats.

    The audio quality of WMA and MP
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    3 audio formats tends to be noticeably different. WMA is a decent quality audio
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    format when streaming at phoneline speeds (maybe 30kbps or so). At such speed WM
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    A almost reaches an FM level of audio quality, although not quite. At 128kbps, M
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    icrosoft claims the WMA is nearly CD-quality, although many would deny this. WMA
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    , however, is not to be completely looked over. The compression provides relativ
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    ely small audio files and they require less processing power to execute. It thus
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    retains a deminishing niche as MP3 has become more popular and widely used.

    Th
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    e MP3 audio compression was developed in Germany in 1991 by the Fraunhofer Insti
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    tute. MP3 typically provides higher quality sound than WMA because it uses perce
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    ptual audio coding to compress CD-quality sound by a factor of 12. As a result,
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    MP3 has become almost the universal standard among audio usage and broadcasting.
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    It provides CD-quality sound at reasonable compression sizes and high streaming
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    speeds. Watch out, however, at low bitrates, as MP3 quality will likely suffer.


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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