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Paper shredders are used in a number of situations. Doctors, dentists, and psychologists use them to protect their clients’ p

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

rivate medical information. Private citizens use them to destroy papers that contain important financial information. Busine

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ses use them to protect themselves from corporate espionage and information theft. Paper shredders cost between $15 and $130,

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

depending on their features.

There are a large number of paper shredders on the market. The two main types are strip cut an

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

cross cut. Strip cut paper shredders slice the paper into thin vertical ribbons. They are good in many situations, but they

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

are not recommended for people requiring maximum security. Cross cut paper shredders cut documents into tiny bits of paper th

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

at are nearly impossible to reassemble. Cross cut paper shredders are generally better than strip shredders for high security

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

situations, but they are also more expensive.

Another thing to consider when buying a paper shredder is how much it will be u

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

sed. Different paper shredders are built to handle different amounts of paper at a time and to operate for different lengths

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

f time before needing a break. It is important not to use the paper shredder above the manufacturer’s recommendations; if the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

are overused or used improperly, they can burn out quickly.

Paper shredders can only be used for a certain amount of time be

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

fore they need to be rested. The length of time depends on the particular shredder. Most instruction manuals that come with

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

he shredders have this type of information. For example, some top of the line models can work for 10 to 12 minutes before nee

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ding to be turned off for 20 minutes. Other models can work for as little as two minutes at a time before needing to be turne

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

off for four minutes.

Another feature that differs between types of paper shredders is the number of sheets that it can take

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

at once. The “throat size,” or size of the opening where the paper is fed, varies between models. Some can handle up to 9 sh

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

eets at once, but most can take about 5. It is recommended that people feed a little less than the maximum in order to keep t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

e machine working properly. Also, the dimensions of the opening need to be considered. It is better not to have to fold a sh

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

eet of paper in order to get it to fit into the shredder. Most shredders can accommodate sheets of paper around 9 inches long

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

This is good for nearly all types of paper, and also works for credit cards, checks, receipts, and other financial documents

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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