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Anyone who works at Target will tell you that a very large part of Target's logistical system is making sure that things are stored in the backroom correc

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tly and in an orderly fashion. At Target a very important evaluation tool is something called location accuracy. In order to understand the concept of

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ocation accuracy you need to understand how the LRT works. The LRT is a device used at Target and at other retail stores to track inventory. At Target t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

he LRT is used for several purposes but most important is its role in stocking the store. When a Target employee who works in the backroom needs to pull

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

n item from the shelf he or she scans the location and then scans the item. The LRT will then display how many products need to be removed from the backr

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

om shelf. After that the employee will then indicate whether or not there are any more on the shelf or not. Location accuracy is simply a measure of how

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

often the employee is right when indicating whether or not there are any products left. Any number that is below ninety-four percent is completely unacc

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ptable. An accuracy of over ninety-seven percent or higher is usually expected.

By placing so much emphasis on location accuracy Target is ensuring that

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

its process of ordering is not compromised by misreported inventory. For instance when a Target employee makes an error, there are dire consequences. If

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

the employee enters on the LRT that there are no products left when there really are then the system will automatically enter in an order for an entire b

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tch. This means that there will be dozens or even hundreds of surplus items in the store. Not only will these items be a waste of money to purchase, but

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

they will also take up more space in the backroom. This causes difficulty when trying to store other items and also makes it more difficult for the emplo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

yees to move around as the stockroom will be cluttered. On the other hand if the employee instead says there are items left when there are none, a diffe

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ent but equally troublesome problem comes up. When the ordering is done at the beginning of the week the item will not be replenished. That means that f

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r the entire week that item will not be sold. Not only will the store lose out on a large amount of sales but it will also have to deal with the unprofes

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

sional look of empty shelves.

There are several reasons why errors are made with location accuracy. Not all of them are the fault of the person who indi

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ated incorrectly whether there were products left on the shelves. The first is that the products placed there are not in a place where they can be seen.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

This usually means that the person who put them there previously put the product behind something else and then when another worker came to remove it, he

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

did not notice it was there. Target places such a large importance on location accuracy because if the inventory reports are not accurate then the logist

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

cal system that they use will not be effective. Having high location accuracy is critical for having the correct number of products in stock at all times

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Today is the last day to affect the end of your current sales cycle - what are you doing to ensure that your year gets off to a strong start?

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